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November 2006

November 30, 2006

Wash U Genome Sequencing Center Recieves $156 M Grant

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This week the National Human Genome Research Institute (NHGRI) announced that the Wash U Genome Sequencing Center has been selected as one of three large-scale sequencing centers to recieve a $156 million, four-year grant. Much of the funding will go towards efforts to study genes involved in human cancers.

Interviewed in the Record, GSC Director Richard Wilson, Ph.D. was optimistic about the grant's effects:

"The Human Genome Project gave us the blueprint of the human genome, and now we're ready to comb that genome to find genetic changes that underlie the development of cancer and sustain its growth. We strongly believe that a genome-wide understanding of cancer will ultimately lead to the development of new diagnostic tests and more effective treatments."

November 28, 2006

Gregor Mendel Exhibit at Chicago's Field Museum

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I just got back from a beautiful Thanksgiving weekend in Chicago. Between gorging on prime rib and turkey at Lawry's and fighting the crowds along Michigan Ave I got a chance to catch an excellent exhibit on Gregor Mendel at the Field Museum.

Like the other exhibit now at the Field, a painfully dry showing of Tutankhamun artifacts, this one is mostly just a garage sale. With that said, though, Mendel's stuff is pretty cool. High on my Christmas list is his copy of Darwin's Origin of the Species, complete with margin notes.

The curators do a nice job of linking the 19th-century scientific atmosphere of with that of today, offering profiles of some current plant biologists including Wash U's own Sonal Singhal, a student in Dr. Barbara Schaal's lab.

Worth checking out if you're ever in the area.

November 27, 2006

Offshoring Shuffles Biotech Landscape

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The San Diego Union-Tribune ran an article worth reading yesterday about the effects of offshoring on the biotechnology sector. Since the investment busts early this decade, investors have been increasingly wary about funding technology startups with lots of promise (blockbuster drug ideas) but few tangible results (clinical data). As a result, investment capital is skewing more and more towards incremental product offerings, those companies developing drugs with existing trial data or repositioning current formulations.

Another solution is the idea of the virtual company: Housing management and a skeleton crew of technical experts in the states and offshoring all of the actual "work" (ie. lab development) to contract firms in India or China. In San Diego, where over 36,000 people work in biotech, this is a major concern. Why keep paying for lab space (and workers) on expensive property when PhD's in Bangalore can do the same job for less? Ivor Royston, one of the fathers of the San Diego biotech sector, has a good quote:

“Today there are more virtual companies, more outsourcing, not a lot of big labs, and fewer lab scientists being hired as we focus on developing clinical products,” said Royston, a partner in the venture-capital firm Forward Ventures. “There is also a growing gap between innovation and product development, between a great idea and being able to develop something for the clinic. And that hurts.”

This issue directly affected St. Louis last year, when software developer Tripos, Inc. lost the bid for a Pfizer drug-discovery contract (along with 2 other US firms) to an offshore company. More broadly though, you have to wonder how the rise of "virtual companies" might shuffle the biotech landscape here. St. Louis lags behind SD and the Bay Area in terms of commercial research infrastructure. If all of the labs are overseas anyhow, though, could smaller regions such as ours benefit from the decentralization? Also, what happens to the tech transfer process if all a startup needs is IP and a contact in China? Interesting things to think about.

More links:

November 26, 2006

Iran: Stem Cell Powerhouse?

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What do Israel and Iran have in common? Besides mild winters and mutual affection, both are apparantly burdgening hubs for stem cell research. Last week, CNN's Ameesh Raman reported on the Iranian effort towards developing ES cell-based cures:

"Iran has some of the most liberal laws on stem cell research. Scientists say the clergy here define life as beginning three months after conception, which gives scientists access to human embryonic stem cells left over from fertilization trials."

Some irony to be found here. Who would've thought that one of the most fundamentalist nations on the planet would turn out so liberal in this regard?

November 25, 2006

Bioenergy and Science on Tap

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Lots going on next Wednesday, if you're so inclined:

  • Science Frontiers: Lighting the Way: Developing Renewable Bio-Energy in St. Louis

    11/29/2006
    5:00 PM
    Washington University in St. Louis, Simon Hall
    Free registration
  • Science on Tap: The Upside of Being Upright


    Herman Pontzer, PhD
    11/29/2006
    7:00 PM
    Schlafy Bottleworks, Crown Room
    No registration required

November 23, 2006

Wash U researchers named to Scientific American's Top-50 list

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On Tuesday, the December issue of Scientific American named Wash U researchers Dr. David Holtzman and Dr. Randall Bateman to their list of the 50 "top movers" in science.

What's the commotion? The neuroscience team is developing a new assay for detecting evidence of Alzheimer's disease in patient cerebrospinal fluid, a thin lubricant bathing the brain and spinal column. Although the basics behind the test have been around for some time, the new method allows researchers to ask more detailed questions about exactly how Alzheimer's and other neurodegenerative diseases progress.

Congrats to Drs. Holtzman and Bateman.

November 18, 2006

Barnes selected as trial hospital for artificial heart

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Today's Post-Dispatch reports that Barnes-Jewish Hospital has been chosen as one of nine institutions nationwide to implant an updated version of the Jarvik artificial heart. The implantable device, invented in the late 70's by recent Lipitor-shill Dr. Robert Jarvik, is currently FDA approved as a transitional aid for patients awaiting a heart transplant. However, many engineers and medical doctors are also interested in its longer-term effectiveness.

The study program will place stringent requirements on both the implantation procedures and patient list, so coordinating any surgeries will be no small task. Despite this, Barnes-Jewish hopes to implant two of the artificial hearts in the next year.

November 17, 2006

First Steps from Bioentrepreneur

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Last month, Bioentrepreneur Online published a great summary of the initial steps towards forming a tech startup. Especially cool is the overview of different incorporation schemes.

Enjoy:

Getting it Right the First Time (Free Registration)

November 16, 2006

Jorge Chen of PhD Comics at Wash U

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Jorge Chen, writer and creator of PhD Comics (http://www.phdcomics.com/) is coming to Washington University as part of his Procrastination speaking tour. If you're a grad student, you probably already know this. However, if you're somehow unfamiliar with the wonder that is PhD comics, you'll want to check it out.

Jorge Chen
"The Power of Procrastination"
Washington University
Lab Sciences Building
Room 300
November 16, 2006 (today!)
5:30 PM

November 15, 2006

Olin Cup Finalists Announced

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On November 9th, Washington University's Skandalaris Center for Entrepreneurial Studies announced its 2006 Olin Cup Finalists. The winning teams were:

Bio Rankings
ChemBionix
Natural Capital
Neurolife
Senetric
Smart DNA Solutions
Social Network Systems

Four of the seven finalists are bio- or med-tech related - Best of luck in the final rounds!

November 9, 2006

Amendment 2 Passes

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It's official, Tuesday evening the Missouri general electorate passed Amendment 2, the Stem Cell Initiative. Contrary to polling earlier this year, the measure passed by a razor-thin margin: 1,077,276 votes for (51%) vs. 1,028,495 votes against. The ballot results were also reflected in the Senate race, where Republican Jim Talent, a vocal opponent of the initiative, lost his seat to Democratic challenger Claire McCaskill, an initiative supporter.

Some interesting links from a variety of angles:

November 5, 2006

Two SLU researchers killed by drunk driver

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Two researchers with the SLU Department of Biochemistry and Molecular Biology were killed late Friday evening when their car was struck by a drunk driver on Grand Ave. Timothy Becker, 30, and his fiancé Monica Gutierrez, 29, worked as research assistants in the department on projects involving hearing and bone disorders.

The other driver, Ebony Fowler, 23, of St. Louis was driving with a blood-alcohol level of 0.219 percent at the time of the crash, nearly three times the legal limit of 0.08. She survived the accident, though her passenger perished. This morning she was charged with three counts of vehicular manslaughter.

This story is a tragedy, and the loss of these three innocent people is a tremendous blow to our city.

US biotech firms unimpressed with traditional grad school curriculums

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Businessweek reports today on a growing opinion within the national biotech industry that an increasing number of graduate students are entering the workforce unprepared for commercial R&D. Particularly lacking are math and computer skills, and experience with the FDA regulatory environment - especially with regard to process control and statistical QC.

The answer? For many biotechs, including Southern California's Invitrogen, it lies overseas. Many researchers on student or work visas commonly recieve training in the multidisciplinary fields now being applied to drug design. These individuals are in such demand, in fact, that companies interested in these skills are having trouble finding enough to go around.

Good a reason as any to take that extra computer class.

Danforth Center ranked as one of the "Best Places to Work in Academia"

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Earlier last month, the Danforth Plant Science Center was ranked # 15 on the The Scientist's list of the "Best Places to Work in Academia in 2006". Congrats to the Danforth Center and their gorgeous building. One question though: How did Wayne State University in Detroit land at #14? Even with the the comparatively-idyllic surroundings, you would think that recent world events would put the St. Louis institution ahead.

The University of Missouri - Columbia also made the list at #33, up from #44 in 2005.

KFC announces switch to low-linoleic soybean oil

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In a move with important implications for GM soybean manufacturers, KFC (the chic
ken place) announced last week that they will be converting all 5,500 of their U.S. restaurants to use low-linoleic soybean cooking oil. The new oil, which reportedly tastes the same as traditional partially hydrogenated oil, contains zero grams of trans fat, a preservative linked to a wide range of cardiovascular diseases.

Monsanto, a leading producer of the GM soybeans, welcomed the decision. Besides the sales implications, KFC's acceptance of the oil is a key corporate vote-of-confidence for the new GM product, and paves the way for similar decisions by other fast-food chains.

Kansas City recieves Missouri tax credits for biotechnology center

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From the St. Louis Business Journal, the Missouri Department of Economic Development announced on Thursday that the KC Biotechnology Center will recieve $150K in state tax credits for business development programs. The center focuses on incubating early-stage medical companies, and currently houses one tenant, Proteon Therapeutics, Inc.

November 1, 2006

National expert in cancer prevention joins Siteman Center

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Dr. Graham A. Colditz
On October 25th, the Siteman Cancer Center announced that Dr. Graham A. Colditz, a leader in cancer prevention and epidemiology at Harvard University, would be joining the center as the Niess-Gain Professor and associate director of Prevention and Control. Congrats to the center for the high-profile gain, and a hearty welcome to Dr. Colditz!

The opinions expressed herein are soley those of the author and do not represent the views of any other individual or group, unless expressely stated.
Copyright © 2006-2007, Brian Loyal. All rights reserved