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May 2007

May 31, 2007

Monsanto Chief Predicts Increased Demand for Engineered Crops

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Monsanto CEO Hugh Grant
Addressing stock analysts in New York on Wednesday, Monsanto CEO Hugh Grant predicted that future agricultural challenges will increase demand for biotech crops featuring multiple engineered traits. Grant suggested that increased global temperatures could require plants to have better drought resistance and a skyrocketing demand for ethanol could lead farmers to plant corn under sub optimal pest and soil conditions. He continued by stating that Monsanto will look to gradually move away from its chemical pesticide and fertilizer businesses towards a greater emphasis on biotechnology in the future.

(...more from iht.com)

In other Monsanto news, today the company announced that it had reached an agreement with the U.S. Department of Justice over its acquisition of Delta and Pine Land Company (D&P), a major supplier of cottonseed. Per the new arrangement, Monsanto will divest its current branded cottonseed business to several competitors. Monsanto expects to utilize D&P's extensive stores of cotton germplasm to improve its efforts in generating engineered cotton traits.

(...more from monsanto.com)

May 30, 2007

Two Wash U Programs Prepare Researchers for Clinical Studies

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This month, the Washington University School of Medicine granted its first degrees and certificates in a pair of programs designed to prepare researchers for clinical investigations. The Mentored Training Program in Clinical Investigation (MTPCI) and Predoctoral Interdisciplinary Clinical Research Training Program (PICRT) are aimed at educating professional students in topics such as clinical study design, statistical analysis and data management and research ethics. The MTPCI offers a master's degree to junior faculty, fellows and postdoctoral students, while the PICRT provides a training certificate to doctoral students. Both programs were designed as part of the university's Biomed 21 program to help bridge the gap between academic research and clinical practice.

(...more from biomed21.wustl.edu)

May 29, 2007

Casual Tuesday: Newsweek Catches a Synthetic Fever

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As a bioengineering undergrad, one of the hardest things to put up with was our discipline's rumored lack of engineering street cred (we stopped caring in grad school). All of the mechanical engineering students got to come home with their robots. The structural folks built bridges and the comp-sci kiddies published games and web apps. But the bioengineers? We, um.....read a lot of biology textbooks.

Bioengineers love the burgeoning field of synthetic biology. If we could, we'd take it out to dinner. Why the affection? Synth-bio lets us build cool stuff. Synthetic biology is the study of how to break living processes down into their most fundamental components and reassemble them into something new and useful. Imagine a big bucket of gooey Legos, where the blue one can break down sugar into energy, and the small yellow one can replicate DNA or synthesize a nanofiber.


(For an even better intro, check out this comic strip from MIT)

This week, our crush got a big boost from a cover story on the online edition of Newsweek fittingly entitled, "Life 2.0". The story describes a group of loosely-connected scientific teams all striving to synthesize unique tools (most for the field of industrial biotechnology) from biological starting materials. From George Church, Harvard guru of genetic sequencing, trying to develop a biological "chassis" by reducing a cell down to only its most necessary components, to Jay Keasling at UC Berkeley (Who I saw give a fantastic seminar last summer), recipient of a $42 million Gates Foundation grant to engineer yeast to produce a malaria drug, the work covers a marathon of fields.

It also might be the first time I've heard Francis Collins and Leon Kass portrayed as such best buddies. A stretch, much?

NEWSWEEK: Life 2.0

Events for the Week of May 30th - June 1st

  • Science On Tap
    Cognitive Illusions: How the Mind Bends Reality
    Henry L. Roediger, III, PhD
    Crown Room, Schlafly Bottleworks
    7260 Southwest Ave
    Maplewood, MO
    Wednesday, May 30th
    7:00 PM

May 24, 2007

St. Louis RCGA Named a "Top-10" Economic Development Groups

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The May issue of National Site Selection Magazine named the St. Louis Regional Chamber and Growth Association (RCGA) to its list of the Top-10 performing economic development groups for 2006. The magazine considered factors such as regional capital investment, job creation and breakthrough deals to compile the list. Supporting its inclusion of the St. Louis group, the article cited advancing life science projects at Biovest and the Wash U Genome Sequencing Center, as well as regional job growth and the recent downtown development boom.

The RCGA has always been a big booster of this website, and they deserve every bit of praise that comes their way. Congratulations, guys.

(...more from stlrcga.org)

May 22, 2007

Monsanto Announces Gene Stacking Partnership with Chromatin, Inc.

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A Chromatin Scientist
Monsanto announced this morning it has entered into a collaborative agreement with Chicago-based Chromatin, Inc. to develop that company's plant gene stacking technology. The non-exclusive license will allow Monsanto to apply the new technique towards enhancing their corn, cotton, soybean and canola products.

The Chromatin technology bundles multiple engineered traits into a heritable "mini-chromosome". These assemblies include many features of natural plant chromosomes, such as intact centromeres, increasing the stability of the desired traits. Chromatin claims that the technology "could accelerate the speed-to-market for plants modified with a single trait by two to three years (25 percent to 40 percent)".

(...more from Monsanto.com)

May 21, 2007

Danforth Center Recieves $3 Million+ Grant from Buffett Foundation

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Yesterday, the Donald Danforth Plant Science Center announced that it had recieved a grant of over $3 million from the Howard G. Buffett Foundation to fund research towards engineering an enhanced sweet potato for African farmers. As part of the gift, the Danforth Center will create an international agricultural research consortium involving groups in Peru and Uganda. This effort will employ technology donated by Monsanto to improve the sweet potato's resistance to a pair of viral strains while improving its nutritional value.

The Danforth Center expects to release initial results from the project in late 2008.

(...more from DanforthCenter.org)

May 18, 2007

Casual Friday: This-to-That

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Some more fun with nerd sites. If you've ever wondered what's the best glue for sticking fabric to metal, or vinyl to ceramic, or any other combination, This-to-That will take your material information and output the best adhesive for the job.

There's some fun glue trivia too. Did you know:

  1. "The famous cow used as the corporate symbol on all Elmer's products is actually named Elsie, and she is the spouse of Elmer, the bull (male cow) who the company is named after"
  2. "The United States Postal Service assures its customers that they will not get fat licking stamps. There is no more than one-tenth of a calorie's worth of glue on every stamp."
  3. The glue used to manufacture cigarettes is completely non-toxic, made from a combination of milk protein and wax.

Events for the week of May 21st - May 25th:

May 15, 2007

Three Wash U Scientists Elected to the National Academy of Sciences

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Three professors at Washington University were among 72 scientists elected to the National Academy of Sciences for 2007. The work of the three covers a wide range of topics in physics and bioscience:


  • Wayne M. Yokoyama, M.D., the Sam J. Levin and Audrey Loew Levin Professor of Research in Arthritis and professor of medicine and of pathology and immunology

  • Aaron Ciechanover, M.D., D.Sc., visiting professor of pediatrics at the School of Medicine and the Research Distinguished Professor of Biochemistry at Technion-Israel Institute of Technology in Haifa, Israel

  • Clifford M. Will, Ph.D., the James S. McDonnell Professor of Physics in Arts & Sciences

Congrats!

New Wet-Lab Developement May Get State Incentives

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A new wet-lab facility planned for a vacant site next to the Donald Danforth Plant Science Center moved one step closer to reality last week, as MO Governor Matt Blunt sat down with executives from the development company to discuss the potential for public incentives. Baltimore-based Wexford Science & Technology LLC has been eyeing the site for several months now, but has stated previously that it would need public funding to help potential tenants, credit-poor biotech startups, pay their share of the construction costs. Nothing definite seems to be in place as of yet, but both sides expressed their optimism for the deal.

In addition, it seems that the St. Louis Community College may be interested in anchoring the development, providing another source of funding for the potential project.

(...more from stltoday.com)

May 14, 2007

Pfizer to add $100 Million to Planned Expansion in Chesterfield

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Pfizer announced it plans to spend $100 million on expanding its biologics production capabilities at the company's Chesterfield campus. The project will expand on a $200 million addition at the site scheduled for completion by the end of 2008.

The Chesterfield location has been something of a favorite lately for the pharmaceutical giant, escaping relatively unscathed from several recent rounds of international job cuts. Pfizer's St. Louis labs include the Center of Emphasis for Global Biologics, a vital part of the company's efforts towards developing protein-based therapeutics. The $100 million addition will help to strengthen these efforts, with the largest portion spent on expanding Pfizer's only government-certified biologics test plant.

(...more from stltoday.com)

Wash U Engineering Team Developing Nanostructured Energy Converters

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A team of Wash U engineers led by Dr. Pratim Biswas recently described a new way of producing nanostructured photocatalytic devices. Photocatalysts convert light energy, either from the sun or an artificial source, into more convenient forms such as electricity or hydrogen. Current devices rely on silicon wafers which do the job, but at relatively high costs and low efficiencies. Using the new technique, the Wash U team was able to use specific metal oxides, instead of silicon, in a highly-controlled microenvironment to produces devices with greater stability for lower cost. The data was presented during the recent International Symposium on Energy and Environment at Wash U.

(...more from wustl.edu)

May 11, 2007

Casual Friday: Bike to Work!

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After mountain biking for years, a few weeks back I finally broke down and went in for an entry-level road bike, a beautiful Fuji Newest 1.0. Imagine my joy, then, to find out that next Friday (May 18th) is national Bike-to-Work Day.

Tired of traffic and high gas prices? Hit the pedals instead, and stop by the rest stops at the Missouri History Museum, Missouri Botanical Gardens and Memorial Park in Clayton for a free continental breakfast provided by Companion Bakery.

Upcoming Events for May 14th - May 18th

    Not a whole lot...use the week to tune your bike!

May 9, 2007

Stereotaxis Reports Record 1Q Revenue

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This morning, Stereotaxis reported a first quarter revenue increase of over 400% from the same time last year. Much of the increase is as a result of increased orders for the company's Niobe magnetic catheter guidance system and associated consumables. The announcement kicks off a busy few days for the company, whose technology will be featured in over a dozen technical presentations at this weekend's annual meeting of the Heart Rhythm Society in Denver, Colorado.

(...more from stereotaxis.com)

May 8, 2007

SLU to Lead National Smallpox Study

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Saint Louis University announced last Monday that its Center for Vaccine Development will lead a national study of a new smallpox vaccine. The World Health Organization officially eradicated smallpox in 1980 as part of a concerted global effort. Nonetheless, many people fear that stored stockpiles of the virus could be used as a bioterror weapon.

The study will test the effectiveness of Imvamune, a new vaccine thought to have fewer side effects than its decades-old predecessor. In all, the study will involve seven research institutions and over 200 test subjects.

(...more from Forbes.com)

May 7, 2007

MO Political Roundup

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Ah, DC. The glistening capital dome, the murmuring halls of union station, the hour-long commute from Dulles to downtown (How was I supposed to know there were 2 airports!?). With EB 2007 said and done (so many, many people) the mind turns to things political...

I didn't get a chance to update before I left town, but the past few weeks have seen developments in some important MO life science legislation:

1. The Lewis and Clark Discovery Initiative

First proposed nearly a year and a half ago by Governor Matt Blunt, the Lewis and Clark Discovery Initiative promised to shift $300 million from MOHELA, the state-sponsored student loan authority, towards various education-related capital projects. Included in this list was a variety of life science facilities, including new facilities at UMSL, the Center for Emerging Technologies and, perhaps most significantly, an $80+ million cancer research center at the University of Missouri - Columbia.

The project has since run into opposition from both sides of the political spectrum. Between Democratic concern for the viability of MOHELA after the sale, and Republican fear of potentially supporting stem cell research, a heavily-modified bill lacking nearly all life science programs ran aground on a Senate filibuster in March.

Debate on the issue was finally resumed on April 19th, when Senate Republicans mustered enough votes to pass the bill. Gone are the CET facilities, the cancer center and other once-hoped for projects. Replacing them: some isolated agricultural projects and, just to rub salt into the wound, a complete lack of funding for any major new facilities at Mizzou - seen by many as retaliation for the Democratic filibuster.

So, all in all a pretty discouraging result. The one consolation for the biotech community is this: The Initiative was controversial for several reasons besides simply containing life science projects. If, as some opponents claim, the payout manages to bring Missouri's higher educational system to the brink of collapse, perhaps it will be better in the long run that the state life science community isn't wrapped up too tightly in the process.

2. Life Sciences Research Trust Fund

In happier news, some progress has been made in providing the first scheduled transfer of funds into the state Life Sciences Research Trust Fund. Originally created in 2003 to help spend money from Missouri's tobacco settlement, the funding process hit a series of snags in previous year from, who else, conservative special interest groups. This year, the appropriations are especially important due to their potential use in a pair of federal proposals, for new bio-defense and energy centers.

Right out of the door, the bill ran into trouble. MO House Republicans successfully reduced the funding amount from Gov. Blunt's original $33 million down to $15 million, eliminating nearly all human life science funding. What's more, there was some speculation that even that reduced amount would fail to see the light of day. Such an action would virtually eliminate Missouri as a contender for the federal centers and permanently affect the regional life science sector.

Responding to these real dangers, Sen. Graham (D-Columbia), Sen. Bray (D-University City), Sen. Callahan (D-Independence), Sen. Coleman (D- St. Louis) and Sen. Wilson (D-Kansas City) rather heroically fought for passage of the bill and removal of any language limiting use of the funds. They were partially successful. Although the bill was finally passed, appropriating $13.5 million to the trust fund, it explicitly prevents any money from going to human life science research. The relevant section (7.020) reads:

Section 7.020. To the Department of Economic Development
For the Life Sciences Research Board for distribution of grants or
contracts to Missouri private and not-for-profit institutions to fund
projects relating to increasing Missouri's research capacity, as
provided in Sections 196.1100 through 196.1130. The Life
Sciences Research Board shall submit to the Chairman of the
Senate Appropriations Committee and the Chairman of the House
Budget Committee a spending plan for the period from July 1,
2007 to June 30, 2008 no later than December 1, 2007 detailing
the projects and institutions to which it will distribute grants or
contracts. Projects should be limited to bioenergy projects,
National Bio- and Agro-Defense Facility projects, Gateway Fund
projects, Animal Health Corridor projects and/or Odor
Abatement/Water Quality projects
From Life Sciences Research Trust Fund .......$13,455,465

This extra language (plus a loss of $1.5 million) differs from the House version, so the two bodies are in the middle of conference committee negotiations. Public hearings wrapped up last Friday, so hopefully we should hear about the final details in the next few days.


In all, a busy few weeks. We still haven't seen the glowing show of state support that everyone has been waiting for to push the biotech sector onto the next level of development - at this rate we may never will. But apart from the money, it's troubling to think that people still view science as morally objectionable. Missouri's scientists and engineers are ordinary individuals who have dedicated their lives to improving the human condition, often for little pay or publicity. So tell me, why do we need to convince anyone that we're not a bunch of baby-killers?

The opinions expressed herein are soley those of the author and do not represent the views of any other individual or group, unless expressely stated.
Copyright © 2006-2007, Brian Loyal. All rights reserved