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August 2007

August 31, 2007

Danforth Center Breaks Ground on $5.25 Million Greenhouse Expansion

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On Tuesday, the Donald Danforth Plant Science Center officially broke ground on a $5.25 million, 15,300 square-foot greenhouse expansion for its Creve Coeur campus. The Jack Taylor Family (of Enterprise Rent-a-Car fame) and the Danforth Foundation contributed a combined $3.5 million, while the MO Development Finance Board provided additional funding in the form of state tax credits.

The new expansion will provide workspace to house the large plants and additional scientists needed to conduct research into renewable biofuels. Construction is scheduled to be complete by September 2008.

(...more from danforthcenter.org)

August 27, 2007

Post-Dispatch: Anti-Stem Cell Measure "Overheated", "Misleading"

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This morning, the Post-Dispatch published an editorial regarding last week's anti-stem cell research activity. In case you missed it, here it is in its entirety:

Sowing confusion

08/27/2007

Most people regard human cloning as a process that results in the birth of a human being. In Missouri, that process is illegal and, since last fall, unconstitutional.

But nine months after voters approved a constitutional amendment that protects stem cell research conducted in Missouri if it's permitted under federal law, opponents have launched yet another drive to overturn it. Similar efforts failed in the Legislature earlier this year.

The opponents insist that voters didn't know what they were doing when they voted in favor of Amendment 2 last year. But their overheated rhetoric and misleading arguments threaten to sow more confusion.

At issue is a process called somatic cell nuclear transfer, SCNT. It's a technique that researchers hope might be used someday to grow human embryonic stem cells, although they have not yet had success with using the technique with a human egg.Advertisement

A group called Cures Without Cloning has started an initiative drive to redefine SCNT as human cloning, ostensibly making it illegal. The new definition is needed, a spokeswoman for the group argues, because "the Missouri constitution currently has confusing language which allows the same method of cloning that was used to create Dolly the sheep."

The comparison is faulty, almost like saying a trip to the corner grocery is the same as a trip to the West Coast, because both require getting your car out of the driveway. Creating Dolly through cloning involved much more than using SCNT to induce a sheep egg to begin dividing and developing. It also involved implanting that egg into a womb and keeping it there for a full term of pregnancy so a sheep could be born.

Taking such steps in connection with a human egg is illegal. Right now.

The painful irony of this new initiative is that, if it were to succeed, Missouri's Constitution would contain two conflicting definitions of human cloning. When a challenge arose, the state courts would be forced to decide which definition was valid — raising the specter of "activist judges."

The additional irony is that the supporters of this latest effort already have achieved their goal. On June 28, the Stowers Institute for Medical Research in Kansas City announced that it would postpone a planned expansion because the unsettled political climate in Missouri has made it impossible to recruit top scientists in the field.

We should be encouraging responsible medical research, conducted according to strict ethical guidelines, into possible treatments and cures for deadly and debilitating diseases. We should be welcoming top scientists to help nurture good jobs and future economic development. Instead, even though voters already endorsed protections for embryonic stem cell research, we're allowing those those scientists to be driven away.

Novus International Breaks Ground on New $20 Million Headquarters

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Novus International, a livestock nutition supplier, broke ground last week on a new $20 million headquarters building near their current facility in the Missouri Research Park. The company has partnered with Forum Studio Inc. and Clayco to develop a green design, aiming for eventual LEED platinum certification. Novus manufactures a variety of animal feed supplements, preservatives and vaccines, and serves customers in over 80 countries.

(...more from msn.com)

Monsanto Moves Towards Drought-Tolerant Crops

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There's a nice article in last week's US News and World Report about Monsanto's recent efforts towards developing drought-resistant crop strains. It also manages to give a good Cliff-notes version of the companies recent history, if you're interested.

(...more from usnews.com)

August 22, 2007

Caveman Watch: New Group Proposes Anti-Stem Cell Research Measure

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AP reported today that a new special interest group, Cures Without Cloning, has filed papers with the Secretary of State's office to include a measure restricting stem cell research on next year's statewide election ballot. The new measure would seek to ban somatic cell nuclear transfer, a technique to generate new stem cell lines. Currently, such a procedure is allowed under last year's Amendment 2, so long as the resulting cells aren't implanted into a human womb.

Oddly enough, the measure doesn't actually remove the current protections - if passed, the MO constitution would be in the awkward position of both protecting and banning the same procedure. The Missouri Coalition for Lifesaving Cures, leading supporter of last year's Amendment 2 efforts, has yet to comment on the language in the new measure.

(...more from stltoday.com)

[UPDATE 10:53PM: Apparantly MO Attorney General Jay Nixon and (unofficially) Governor Matt Blunt, both candidates in the Governor's race for 2008, have come out in opposition to the new measure - via stltoday.com)

Wash U Med Joins Major Cancer Research Partnership

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Washington University announced on Tuesday that it had joined the Multiple Myeloma Research Consortium (MMRC), an organization of 13 leading U.S. academic research centers. Multiple myeloma is the second most common blood cancer, affecting over 50,000 people in the United States. Although current treatments have helped patients live slightly longer, there still is nothing near a cure. What's more, recent years have seen an increase in the disease's prevalence.

As part of the MMRC's goal of developing new therapies, member organizations are able to better coordinate their research projects and share sample materials. The consortium also works to guide patients towards promising clinical trials. Washington University School of Medicine serves as a major center for multiple myeloma treatment and research in the St. Louis area.

(...more from mednews.wustl.edu)

Pfizer Breaks Ground on $50 Million Biologics Plant

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Pfizer broke ground today on a $50 million expansion to their biologics production facility in Chesterfield, signaling a new commitment to their St. Louis campus. Biologics are a class of advanced pharmaceuticals that rely on antibodies and other large molecules to treat disease. Manufacturing such materials often relies on extensive cell culture facilities, such as those on the Chesterfield site, rather than the traditional chemical synthesis techniques used to produce small-molecule drugs.

In all, Pfizer plans on doubling the current size of the current biologics plant, allowing it to manufacture the larger amounts of materials required for late-stage clinical trials. The company hopes that as much as 25% of its drug-development pipeline will eventually consist of biologic treatments.

(...more from stltoday.com)

August 16, 2007

Wash U Med Receives $5.7 Million Grant for Kidney Disease Research

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Last week, Washington University announced that its medical school had received a $5.7 Million grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). The money will go towards the creation of a new center for kidney disease research to be led by Marc R. Hammerman, M.D., the Chromalloy Professor of Renal Diseases in Medicine.

An estimated 19 million Americans have chronic kidney disease, characterized by a gradual worsening of renal health. Drug treatments are available, but many of these are too broadly targeted to provide specific relief. The goal of the new center will be to conduct basic research on how the kidney develops, in hopes of identifying the underlying pathways for renal disease more precisely.

Wash U was one of only three institutions to receive NIDDK funding. The project will encompass 43 researchers at the medical school, plus 11 investigators from around the world.

(...more from mednews.wustl.edu)

August 13, 2007

Four “Centers of Excellence” Designated by Life Science Research Board

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Last week, the Missouri Life Science Research Board announced the creation of 4 "Centers of Excellence" in St. Louis, Kansas City, Springfield and Columbia. This year, the MO legislature appropriated $13.5 million to be split among the groups, limiting the use to mostly agricultural and animal health projects. It was hoped by many that most of this funding would have gone towards MO's proposals for one of two federal research centers. However, since MO's teams were eliminated from consideration in June, the money is now available for other projects.

The St. Louis center will be chaired by Robert Beachy, President of the Danforth Center, and includes a number of plant-research institutions: Donald Danforth Plant Science Center, Missouri Botantical Gardens, Saint Louis University, University of Missouri-St. Louis, and Washington University.

(...more from ded.mo.gov)

August 4, 2007

Off for Vacation!

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I'll be on vacation for the next week, so no posting till I get back. Till then, here are a few stories I missed over the past few days:

Center for Emerging Technologies Announces Expansion Plan

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This week, the Center for Emerging Technologies officially announced a 60,000 square-foot expansion to its incubator space in the Central West End. The new building, the third for the center, will cost an estimated $27 million, $200,000 of which will be provided by the Ameren Community Development Fund. In all, roughly 60% of the expansion will be wet lab space for new life science start-ups. Cannon Design, a national architectural firm credited with designing the SLU life science building, the new Solae headquarters and Washington University's Biomed 21 complex, was selected for the schematic design.

This news, plus the recent approval of new incubator space in Creve Couer, should go a long way towards feeding the regional hunger for more commercial lab space.

(...more from stltoday.com)

(...more from emergingtech.org)

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